Overview

Hit recognition is a powerful tool for discovering compounds with the desired activity against a fully validated target. Hit recognition is an important step in the drug discovery process in which the identified small molecule will bind to a target, usually DNA modifying enzymes, or other proteins. As a result, scientists can modify its function and improve its biological activity. Identifying the right hit is key in research because it reduces the attrition rate. Depending on the nature of the project, Creative Enzymes' team applied the most appropriate hit identification method and successfully identified a family of hits that were validated to have the best chance of developing into drug-like compounds.

Sepcific Hit Identification Service Approaches We Offer

To identify high quality persistent hit series, Creative Enzymes selects the following mentioned hit identification methods individually or in parallel, depending on the nature of your project.

• Structure-based virtual screening

Our team can analyze the structural information about your specified target and design the expected ligand. We can also identify any differences that may help in designing selective compounds by overlaying the target on the relevant protein structure.

• Ligand-based virtual screening

We perform ligand-based virtual screening for hit identification when the 3D structure of the target is unknown, and we work to provide the following services.

1. Cluster analysis and identification of subsets of molecules for further development.
2. Quantitative conformational relationship (QSAR) modeling using data management methods and machine learning algorithms.
3. Further exploration of SARs around chemical types of data sets.

• Pharmacophore-based screening

Our team can perform pharmacophore studies on a range of known active compounds using conformational analysis, molecular superposition, etc.

1. Identify common characteristics of a range of known active compounds.
2. Screen the database and identify matches that geometrically fit the pharmacophore profile.

• Similarity-based screening

We perform similarity searches using multiple molecular descriptors (e.g., physicochemical properties, 2D properties, and 3D properties).

Service Process

Our Features

• Creative Enzymes has established a proven enzyme technology platform for a variety of applications. We'll help you design the right hit identification service to aid your scientific research.
• Creative Enzymes is a leading enzyme technology company offering a trusted suite of services and solutions, especially with our extensive experience in hit identification service technology service.

Deliverables

• Results raw data
• Data analysis
• Results analysis
• Summary of relevant parameters

Why Choose Us?

Creative Enzymes is a professional hit identification service provider supporting a wide range of enzyme services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. We have accumulated years, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.