Overview

DNA modifying enzymes can be used as effective biomarkers for disease diagnosis and as potential targets for anti-cancer therapy and drug screening, and the development of efficient detection of DNA modifying enzymes is important for biomedical research, clinical diagnosis and drug discovery. The development of biosensors for efficient detection of DNA modifying enzymes is of great importance for biomedical research, clinical diagnosis and drug discovery. Creative Enzymes provides you with a variety of binding site prediction of DNA modifying enzyme service to meet your scientific research needs.

Binding Site Prediction Service We offer

• Template-based: those that utilize homologous or similar structures with known binding sites.
• Geometry-based: those that perform some sort of geometric calculation to identify binding site pockets.
• Energy-based: those that use hypothetical ligands as binding probes to calculate interaction energies.
• Propensity-based: those that calculate the propensity of a property, indicating a statistically significant preference for a known LBS over a non-LBS.
• Combination-based and others: those that make predictions based on the results of other methods, and those that do not easily fit into one of the above categories.

Bioinformatics Platform

• BAPPL

Binding free energy of non-metallic protein-ligand complexes calculated using an empirical scoring function based on all-atom energy.

• BAPPL-Z

Binding affinity prediction for zinc-containing protein-ligand complexes.

• FoldX

Calculating binding energy.

• cons-PPISP

A consensus neural network method for predicting interaction sites.

In Vitro Enzymatic and Molecular Interaction Analysis Technology Platform

• Fluorescence analysis methods: HTRF, TR-FRET, FP, etc.
• Light-emitting methods: Kinase-Glo; ADP-Glo, etc;
• Absorption light analysis methods: UV; VI;
• Non-labeling screening method: SPR.

SPR Technology Introduction

SPR, Surface Plasmon Resonance, reveals the interactions between proteins and other biomolecules through physical optical effects, helping customers to understand molecular functions and screen effective molecules. It is an alternative and superior to tests such as WB/Elisa/CO-IP-/Pull-down/ChIP/EMSA/FRET/yeast two-hybrid, etc.

Service Process

Our advantages

• Custom bioinformatics
• Publication-ready data and figures
• Accurate analysis services available
• A professional and experienced expert team
• Fast turnaround time

Our Features

• We have accumulated many years of essence in the field of binding site prediction of DNA modifying enzyme service, helping customers to speed up project development and improve the overall success rate of the project.
• At Creative Enzymes, simply let us know your specific project needs. We will suggest the best strategy for you.

Deliverables

• Results raw data
• Data analysis
• Results analysis
• Summary of relevant parameters

Why Choose Us?

Creative Enzymes is a company that provides professional and comprehensive binding site prediction of DNA modifying enzyme service. We have years of experience to meet your specific project needs in using enzyme research to add value to your research projects. Creative Enzymes can provide you with personalized solutions to help you thrive every step of the way around your interest in your workflow. If you would like to know more about this service, please feel free to contact us.