Bioinformatics plays an important role in all aspects of protein analysis, including sequence analysis, structural analysis, and evolutionary analysis. In sequence analysis, several bioinformatics techniques can be used to provide sequence comparisons, where new sequences can be compared to sequences with known functions to study the biology of the organism. In structural analysis, many available databases and bioinformatics techniques can help find factors that control protein folding and stability, and predict secondary structure from amino acid sequences. In evolutionary analysis, we use techniques such as phylogenetic trees to find homologous proteins and conserved functional regions. With bioinformatics techniques and databases, the function, structure and evolutionary history of proteins can be easily identified.
Structural analysis provides information on factors related to enzyme folding and stability, interactions between amino acid residues and with surrounding media. The information obtained from the structural analysis will enhance the prediction of secondary and tertiary structures. In addition, the secondary structure information is able to predict the three-dimensional structure of the protein and the enzyme stability after mutation. We offer ASA (solvent accessible surface area) calculation services.
Evolutionary analysis involves the study of homologous proteins, functionally conserved regions, and protein evolutionary history. We use phylogenetic trees for evolutionary analysis. Phylogenetic trees consisting of roots, nodes, branches and tips can be used to infer the history of protein families and detect co-evolution between protein families using ancestral protein sequence reconstruction.
Sequence analysis provides information about amino acid residue preferences and their distribution along the sequence to understand the secondary and tertiary structure of proteins and their function. We offer several sequence analysis tools, such as PSI-BLAST (Position Specific Iterative BLAST), a method better suited for searching sequence databases with similar query sequences, and ClustalW, a multiple sequence alignment program for biomolecules.
Creative Enzymes is a professional DNA modifying enzyme bioinformatics service provider supporting a wide range of enzyme services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. We have accumulated years of quintessence in the field of DNA modifying enzyme service, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.
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