Alkaline phosphatase (ALP) is an important monophosphate hydrolase present in all human tissues, catalyzing the hydrolysis of phosphate groups in carbohydrates, proteins and nucleic acids, and playing an important role in regulating various biological processes such as cell division, proliferation, apoptosis and signal transduction. Abnormal levels of ALP can induce many human diseases (e.g., bone disease, cardiovascular disease, inflammation) and cancers (e.g., oral cancer, prostate cancer, and liver cancer). and hepatocellular carcinoma). Importantly, due to its substrate specificity, high catalytic activity, good stability and low cost, it is widely used for biomolecular monitoring, histochemical staining and gene expression analysis. Therefore, the development of simple, specific and accurate methods to detect ALP activity is of great importance in biological research, drug discovery and disease diagnosis.
DNA-AuNP has become one of the most versatile hybrid nanomaterials for bioanalysis. Spherical nucleic acid nanoprobes with high oligonucleotide loading offer significant advantages in terms of detection sensitivity and specificity compared to linear oligonucleotide-based sensors. Creative Enzymes DNAzymes obtained by in vitro selection have unique recognition capabilities and catalytic properties for specific metal ions. DNAzymes can be further incorporated into other nucleic acid amplification techniques (e.g. RCA, strand displacement amplification (SDA), HCR) to improve detection sensitivity.
Creative Enzymes is a professional alkaline phosphatase detetion service provider, supporting a variety of enzyme-related services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. Creative Enzymes has accumulated years of quintessence in the field of alkaline phosphatase detetion service, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.
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