High throughput screening (HTS) of diverse compound libraries is an important source of hit compounds. Analytical automation and technological advances continue to have a significant impact on the scope, pattern, and disease relevance of HTS activity. HTS analysis is only the beginning of a hit discovery approach, followed by a well-thought-out cascade of counter, orthogonal, selective, and secondary analyses to determine the optimal hit series, which helps lay the foundation for the next hit to the lead phase. Creative Enzymes provides you with a variety of high-throughput screening of restriction enzyme inhibitors service to meet your scientific research needs.

Figure 1. Our workflow for high-throughput virtual screening.

Sepcific High-throughput Screening of Restriction Enzyme Inhibitors Approaches We Offer

Creative Enzymes offers practical high-throughput virtual screening in a competitive manner. We have prepared the most convenient service for you.

• Molecular Docking

We use molecular docking to find interactions between ligands and restriction enzymes, and the optimal binding mode between them, through the principle of spatial structural complementarity and energy minimization in the active site region of the receptor. Our team supports rigid docking, semi-flexible docking and flexible docking to study the behavior of small molecules at the target protein binding site.

• Pharmacophore Modeling and Screening

Creative Enzymes can perform pharmacophore modeling based on "receptor-ligand" interactions, consistent pharmacophore modeling based on active compound structures, automated pharmacophore modeling based on bulk compound activity data, and more. Our pharmacophore modeling and screening services can be successfully applied to conformation building, scaffold jumping, and target fishing.

• Reverse Virtual Screening

Creative Enzymes applies molecular docking-based reverse virtual screening for our clients. We can construct potential target datasets, detect binding sites, and improve the accuracy of search algorithms and scoring functions. Our proven reverse virtual screening process can be used for a variety of applications such as target identification, drug repositioning, and side effect studies.

Related Software

• Autodock, Autodock vina, MOE, Schrödinger, etc.
• MOE and Schrödinger are both commercial software, and Autodock vina is suitable for article publication.

Advantages

• Creative Enzymes offers professional high-throughput screening services. We offer a variety of screening options that you can choose from to suit your needs.
• Creative Enzymes will complete your project on time and efficiently. We have a professional after-sales service: we provide efficient and feasible solutions for our customers.

Service Process

Our Features

• Creative Enzymes will complete your project on time and efficiently. We have professional after-sales service.
• Creative Enzymes works with scientists from many biotechnology companies. We have extensive knowledge and experience to provide quality assurance services.

Deliverables

• Screening results raw data
• Data analysis
• Image and result analysis
• Results analysis
• Screening assessment report
• Summary of relevant parameters

Why Choose Us?

Creative Enzymes is a professional high-throughput screening of restriction enzyme inhibitors service provider, supporting a variety of enzyme-related services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. Creative Enzymes has accumulated years of quintessence in the field of high-throughput screening, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.