DNA modifying enzymes are responsible for the cleavage, labeling, ligation and elongation of genomic DNA, and are involved in various cellular processes such as cell proliferation, differentiation, aging and apoptosis. The detection of DNA modifying enzymes is essential for basic biomedical research, clinical diagnosis and anti-cancer drug discovery. Virtual screening (VS) methods offer significant advantages. High-throughput virtual screening methods can rapidly screen potentially active drug molecules from large compound libraries, with positive rates typically in the range of 5% to 20%. Creative Enzymes provides you with a variety of DNA modifying enzyme service to meet your scientific research needs.
Creative Enzymes has conducted extensive research in virtual screening of drugs and has extensive hands-on experience and core technologies. Depending on the specific research project, we will provide customers with targeted and cost-effective screening solutions. We can also provide services such as processing of specific databases. All you need to do is provide us with biological information about your target and we will screen the best active compound for you, laying the foundation for further bioactivity evaluation. Services include:
Receptor-based virtual screening is a virtual screening based on molecular docking. It uses the experimentally determined or homologously modeled three-dimensional structure of the receptor biomolecule. Through molecular docking, the binding conformation of the small molecule and the receptor is determined. The binding ability of the protein to the small molecule compound is evaluated based on an affinity scoring function related to the binding energy, and finally the compound with a reasonable binding mode and high prediction score is selected from a large number of compound molecules for subsequent biological use.
Ligand-based virtual screening is a virtual screening based on pharmacological models. It is based on the analysis of the structure, physicochemical properties and activity relationships of existing drugs, and the establishment of quantitative structure-activity relationships or pharmacological models to predict the activity of the screened new compounds.
Creative Enzymes is a professional DNA modifying enzyme ligand screening service provider supporting a wide range of enzyme services. We are able to perform individual tests at the most precise level, as well as design and complete a suite of services as a solution to the subject project. We have accumulated years of quintessence in the field of DNA modifying enzyme ligand screening service, helping our clients accelerate drug discovery and development and improve the overall success rate of their projects. If you would like to know more about this service, please feel free to contact us.
We are here to answer any question you may have
