Basic Assumption of Homology Modeling

If there is sequence, structural and functional homology between protein A of unknown structure and protein B of known structure, then protein A can be used as a template for protein B to build its all-atomic 3D structure. Homology modeling, protein 3D structures are an important basis for understanding their biological functions and for structure-based drug design. With the rapid development of structural biology, the speed of measuring protein 3D structures using methods such as NMR or X-Ray crystallography has been greatly improved.

Sepcific Cloning Enzyme Homology Model Generation Approaches We Offer

Creative Enzymes uses computing simulation methods to build a three -dimensional structure of Cloning enzyme. Among various computer modeling methods, homology modeling is the most mature, most accurate, and most reliable method for technology.

Workflow

• Construction and optimization of structure

This part mainly contains the construction and optimization of restricted enzyme structures. Later, on the basis of modeling enzyme structure, dynamic software was used to simulate molecular dynamics to obtain its optimal structural mode.

• Building Process
• First, the known structural proteins with high sequence similarity are searched for as candidate templates by the sequence similarity search tool for the query sequence (Query).
• Next, the query sequence is aligned with the candidate templates, and one or more combinations of templates are selected as the final templates using sequence identity as the index.
• From then on, the actual modeling stage is entered: after alignment, residues that are identical to the template sequence have all atomic motifs copied from the template, while those similar residues have only backbone atoms taken from the template - side chain motifs are constructed separately, and those missing sequences are filled in by searching a Loop database.

Our Capabilities

Creative Enzymes provides high-quality homology modeling services, the results of which can help researchers understand the structural properties of Cloning enzyme and analyze their "structure-function" relationships, and can be used for drug screening, discovering potential therapeutic agents for a disease, or studying target-drug interactions The results can be used for drug screening, discovering potential therapeutic agents for a disease, or studying the interaction patterns between targets and drugs.

Our Advantages

• Ensure high efficiency and quality of Cloning enzyme analysis services
• Competitive pricing in the Cloning enzyme analysis market
• Timely feedback of results
• Ensure 24/7 online service

Service Process

Our Features

• We have professional after-sales service: which has been established to provide customers with efficient, fast, practical and feasible solutions.
• Creative Enzymeshas in-depth cooperation with many biology companies and research institutes, and has extensive experience in providing them with high-quality services.

Deliverables

• Related experimental results raw data
• Experimental report
• Data analysis
• Image and result analysis
• Results analysis
• Stability assessment report
• Summary of relevant construction parameters

Why Choose Us?

Creative Enzymes provides professional Cloning enzyme homology model generation service to meet the needs of regular customers to determine hits on time and on budget. Creative Enzymes relies on the world-class technical expertise, we provide customers with the best quality one-stop Cloning enzyme service, including the development of experimental procedures according to different experimental needs. Please feel free to contact us for more detailed information, our scientists will tailor the most reasonable plan for your project.